Symbol
Name
ID

Sox2
SRY (sex determining region Y)-box 2
MGI:98364

Phenotype annotations related to digestive/alimentary system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Esophageal atresia	Tracheoesophageal fistula
Disease(s) Associated with SOX2	Esophageal atresia	Tracheoesophageal fistula
syndromic microphthalmia 3

Mouse Phenotypes

delayed palatal shelf elevation

failure of palatal shelf elevation

palatal shelves fail to meet at midline

absent palatal taste bud

cleft secondary palate

abnormal tongue morphology

abnormal fungiform papillae morphology

digestive/alimentary phenotype

abnormal esophagus morphology

abnormal esophageal squamous epithelium morphology

esophageal atresia

tracheoesophageal fistula

abnormal salivary gland morphology

abnormal Ebner's gland morphology

absent anterior lingual gland

absent palatine gland

abnormal stomach morphology

abnormal epiglottis morphology

abnormal digestive system physiology

Availability

Mouse Genotype

Sox2^tm1Lpev/Sox2^tm2Lpev

Sox2^tm1Lpev/Sox2^tm3Lpev

Sox2^tm1Lpev/Sox2^tm4Lpev

Sox2^tm1Rlb/Sox2⁺

Sox2^tm2Lpev/Sox2^tm3Lpev

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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